Professor Lucie Cluver

Lucie Cluver
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Professor of Child and Family Social Work
01865 280370
lucie.cluver@spi.ox.ac.uk

Lucie Cluver is a Professor of Child and Family Social Work, in the Centre for Evidence-Based Social Intervention in the Department of Social Policy and Intervention, and an Honorary Professor in Psychiatry and Mental Health at the University of Cape Town. She works closely with the South African government, USAID-PEPFAR, UNICEF, the World Health Organisation and with other international NGOs, to provide evidence that can improve the lives of children and adolescents affected by HIV/AIDS in Sub-Saharan Africa. 

Lucie is lucky to work with an incredible and dedicated team of PhD students, postdoctoral researchers, and colleagues. Together they lead large-scale longitudinal surveys and randomised controlled trials of interventions, combined with participatory qualitative research.

Lucie is a PI on several ongoing trials in Southern and Eastern Africa, all part of the Parenting for Lifelong Health Initiative – a collaboration between the World Health Organisation, UNICEF and academics to provide evidence-based non-commercialised child violence prevention programs for LMIC. These include the Sinovuyo Teen trial (with Dr Franziska Meinck and Dr Jenny Doubt) – a cluster randomised trial (n=1100, 40 sites) of a program for families with adolescents, the Sinovuyo Kids trial (with Prof Cathy Ward at University of Cape Town and Dr Jamie Lachman) for caregivers of 3-9 year olds, and the Mphatlalatsane trial (with Prof Mark Tomlinson and Prof Lorraine Sherr) for parents of toddlers in Lesotho. The PLH programmes are now being implemented in 16 countries in Africa, Asia and Eastern Europe.

Working with a dedicated team in close collaboration with policymakers, Lucie has pioneered research on ‘cash plus care’ – examining the impacts of social protection and psychosocial care on adolescent health.

Lucie leads the first community-based large panel of HIV-positive adolescents and community controls, including 1500 adolescents in South Africa (with Dr Elona Toska), which integrates qualitative research led by Dr Rebecca Hodes (University of Cape Town). Currently, she leads (with Dr Elona Toska) the first known longitudinal study in Africa to assess pathways to resilience amongst adolescent parent families living with and without HIV. This study will include 700 adolescent parents and child dyads.

Lucie has led three major longitudinal studies: the ‘Young Carers Study’ (2008-2012, with Dr Mark Boyes) was the world’s largest study of risk and resilience amongst AIDS-affected children, following 6000 children longitudinally in South Africa, the ‘Orphan Resilience Study’ (2005-2009 with Prof Frances Gardner) followed 1000 children over four years to identify impacts of orphanhood.
The team’s work has won a number of awards, including an ESRC Oxford University Excellence in Impact Award (2018), a University of Oxford Vice-Chancellor’s Innovation Award (2018), ESRC's Outstanding International Impact Prize (2017), the Philip Leverhulme Prize (2015), the International AIDS Society Young Investigator Award (2014), and the Discovery Clinical Excellence Award (2013). They have published over 100 papers in peer-reviewed journals including the Lancet Global Health, BMJ Global Health, AIDS, JAIDS, J Child Psychiatry and Psychology, Social Science and Medicine, AIDS Care and Prevention Science.

Funders: European Research Council Consolidator Grant, European Research Council 'Horizon 2020’, Medical Research Council, Research England, Janssen Pharmaceutica N.V., part of the Janssen Pharmaceutical Companies of Johnson & Johnson, The Nuffield Foundation, the Economic and Social Research Council, the Leverhulme Trust, the Evidence for HIV Prevention in Southern Africa (EHPSA), a UK aid programme managed by Mott MacDonald, the National Research Foundation (South Africa), UNICEF, USAID-PEPFAR, Ilifa Labantwana, the Claude Leon Foundation, the National Department of Social Development South Africa, the World Health Organisation, the John Fell Fund, the Oak Foundation, University of Oxford’s ESRC Impact Acceleration Account, RIATT-ESA, and the International AIDS Society through the CIPHER grant.

Cluver, L, Pantelic, M, Toska, E, Orkin, M, Casale, M, Sherr, L (in press). STACKing the odds for adolescent survival: Health service factors associated with retention in care and adherence amongst adolescents living with HIV in South Africa. Journal of the International AIDS Society. 

Rudgard, W, Carter, D, Scuffell, J, Cluver, L, Fraser-Hurt, N, Boccia, D (in press) Cash transfers to enhance TB control: Lessons from the global HIV response. BMC Public Health.

Hodes, R. Vale, B, Toska, E, Cluver, L, Dowse, R, Ashorn, M (in press). ‘Yummy or Crummy: The multisensory components of medicines-taking among HIV-positive youth. Global Public Health.

Steinert, J, Cluver, L, Meinck, F, Doubt, J, Vollmer, S (in press) Household Economic Strengthening through Saving and Budgeting: Evidence from a Field Experiment in South Africa. Journal of Development Economics.

Cluver, L. Meinck, F. Toska, E., Orkin, F. M. Hodes, R. Sherr, L. (2018). Violence exposure and adolescent antiretroviral non-adherence in South Africa. AIDS.

Cluver, L, Pantelic, M, Orkin, M, Toska, E, Medley, S, Sherr, L (2018) Sustainable Survival: Which SDGs protect against mortality risk for adolescents living with HIV? Journal of the International AIDS Society.

Cluver, L., Pantelic, M., Orkin, M., Toska, E., Medley, S., & Sherr, L. (2018). Sustainable Survival for adolescents living with HIV: do SDG-aligned provisions reduce potential mortality risk?. Journal of the International AIDS Society, 21 Suppl 1. doi:10.1002/jia2.25056

Cluver LD, Meinck F, Steinert JI, et al. Parenting for Lifelong Health: a pragmatic cluster randomised controlled trial of a non-commercialised parenting programme for adolescents and their families in South Africa. BMJ Glob Heal 2018;3.http://gh.bmj.com/content/3/1/e000539.abstract

Cluver, L., Meinck, F., Steinert, J., Shenderovich, Y., Doubt, J., Herrero Romero, R., . . . Gardner, F. (n.d.). Parenting for Lifelong Health: A pragmatic cluster randomised controlled trial of a non-commercialised parenting programme for adolescents and their families in South Africa. BMJ Global Health.

Cluver, L., & Sherr, L. (2017). Integrating disclosure support into family HIV care.. The Lancet. HIV, 4(12), e534-e535. doi:10.1016/s2352-3018(17)30153-4

Cluver, L. D., Lachman, J. M., Ward, C. L., Gardner, F., Peterson, T., Hutchings, J. M., . . . Redfern, A. A. (2017). Development of a Parenting Support Program to Prevent Abuse of Adolescents in South Africa: Findings From a Pilot Pre-Post Study. Research on Social Work Practice, 27(7), 758-766. doi:10.1177/1049731516628647

Cluver, L. D., Orkin, F. M., Yakubovich, A. R., & Sherr, L. (2016). Combination Social Protection for Reducing HIV-Risk Behavior Among Adolescents in South Africa.. Journal of Acquired Immune Deficiency Syndromes (1999), 72(1), 96-104. doi:10.1097/qai.0000000000000938

Cluver, L. D., Lachman, J. M., Ward, C. L., Gardner, F., Peterson, T., Hutchings, J. M., . . . Redfern, A. A. (2017). Development of a Parenting Support Program to Prevent Abuse of Adolescents in South Africa. Research on Social Work Practice, 27(7), 758-766. doi:10.1177/1049731516628647

Cluver, L, Orkin, M, Boyes, M, Yakubovich, A, Sherr, L (2016) Can Social Protection Improve Sustainable Development Goals for Adolescent Health?. PLOSOne. 11(10): e0164808 

Cluver, L, Meinck, F, Shenderovich, Y, Ward, C, Herrero Romero, R, Redfern, A, Lombard, C, Doubt, J, Steinert, J, Catanho, R, Wittesaele, C, De Stone, S, Salah, N, Mpimpilashe, P, Lachman, J, Loening, H, Gardner, F, Blanc, D, Nocuza, M, Lechowicz, M (2016). A parenting programme to prevent abuse of adolescents in South Africa: a study protocol for a pragmatic cluster randomized controlled trial. Trials. 17. 328.

Cluver, L, Meinck, F, Yakubovich, A, Doubt, J, et al (2016). Reducing child abuse amongst adolescents in low- and middle-income countries: A pre-post trial in South Africa. BMC Public Health. 13;16(1):567 

Cluver, L, Orkin, M, Yakubovich, A, Sherr, L (2016). Combination social protection for reducing HIV-risk behaviour amongst adolescents in South Africa. JAIDS. 72: 96-104    

Cluver, L, Orkin, M, Meinck, F, Boyes, M and Sherr, L (2016). Structural drivers and social protection: Mechanisms of HIV-risk and HIV-prevention for South African adolescents. Journal of the International AIDS Society (JIAS). 19. 2064-6.    

Cluver, L, Toska, E, Orkin, M, Yakubovich, A, Hodes, R, Sherr, L (2016). Achieving equity in HIV-treatment outcomes: Can social protection improve adolescent ART-adherence in South Africa? AIDS Care Equity Special Issue. Suppl  2 73-82

Cluver, L, Hodes, R, Toska, E, Kidia, K, Orkin, M, Sherr, L, Meinck, F (2015). ‘HIV is like a tsotsi. ARVs are your guns’: Associations between HIV-disclosure and adherence to antiretroviral treatment among adolescents in South Africa. AIDS. 29. Suppl 1. S57-65. 

Cluver, L, Orkin, M, Boyes, Ma, Sherr, L (2014) Cash plus care: social protection cumulatively mitigates HIV-risk behaviour among adolescents in South Africa. AIDS. S389-97

Cluver, L, Boyes, Ma, Orkin, M, Pantelic, Mc, Molwena, T & Sherr, L (2013) Child-focused state cash transfers and adolescent HIV-infection risks: A prospective multi-site study in South Africa. The Lancet: Global Health. 1. E362-70

Cluver, L, Orkin, M, Boyes, Ma, Sherr, L, Nikelo, J & Makhasi, D (2013). Pathways from parental AIDS to child psychological, educational and sexual risk: Developing an empirically-based interactive theoretical model. Social Science and Medicine, 87. 185-193

Cluver, L, Orkin, M, Boyes, Ma & Gardner, F (2012) ‘AIDS-orphanhood and caregiver HIV/AIDS sickness status: effects on psychological symptoms in South African youth’ Journal of Pediatric Psychology

Cluver, L, Orkin, M, Boyes,a M & Gardner, F (2012) Persisting mental health problems among AIDS-orphaned children in South Africa. Journal of Child Psychiatry & Psychology. 53 (4) 363-370.

Cluver, L, Orkin, M, Boyes, Ma, Gardner, F, & Meinck, Fc (2011) ‘Transactional Sex amongst AIDS-orphaned and AIDS-Affected Adolescents Predicted by Abuse and Extreme Poverty’. JAIDS 58 (3) 336-43   

Cluver, L, Bowes, L & Gardner, F (2010) Risk & protective factors for bullying victimisation amongst AIDS-affected & vulnerable children in S.Africa. Child Abuse & Neglect, 34 793-803 

Cluver, L, Gardner, F & Operario, D (2007). Psychological distress amongst AIDS-orphaned children in urban South Africa Journal of Child Psychiatry & Psychology & Allied Disciplines 48(8) 755-763

  • Intimate partner violence and receptive syringe sharing among women who inject drugs in Indonesia: A respondent-driven sampling study

    Journal article
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    International Journal of Drug Policy

  • Intimate Partner Violence and HIV Sexual Risk Behaviour Among Women Who Inject Drugs in Indonesia: A Respondent-Driven Sampling Study.

    2018
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    Journal article
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    AIDS and behavior
    Women who inject drugs are disproportionately affected by HIV and intimate partner violence (IPV); however, the link between IPV and HIV remains under-researched among substance-using women in low- and middle-income countries. This study examined associations and additive effects of different forms of IPV victimization (psychological, physical and/or injurious, and sexual) on HIV sexual risk behavior among women who inject drugs in Indonesia. Respondent-driven sampling (RDS) was used to recruit 731 women from Greater Jakarta and Bandung, West Java. RDS-II weighted prevalence of any past-year IPV was 68.9% (95% CI 65.0, 72.6) in Jakarta and 55.9% (95% CI 48.0, 63.5) in Bandung. In separate logistic regressions controlling for socio-demographic covariates, all three forms of IPV showed statistically significant associations with sexual risk behavior. After adjusting for all IPV types, psychological (OR 1.87; 95% CI 1.17, 2.99; p = 0.009) and sexual (OR 1.98; 95% CI 1.22, 3.21; p = 0.006) IPV independently predicted women's sexual risk behavior. Marginal effects models suggested that co-occurrence of multiple forms of IPV had greater adverse consequences: sexual risk behavior was reported by 64.1% of women who did not experience any IPV, but increased to 89.9% among women exposed to all three types. Comprehensive harm reduction services that integrate IPV monitoring and prevention are urgently needed to reduce both HIV and IPV.

  • Mental health in South African adolescents living with HIV: correlates of internalising and externalising symptoms.

    2018
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    Journal article
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    AIDS care
    Although declining in all other age groups, AIDS-related deaths among adolescents are increasing. In the context of HIV, mental health problems are associated with negative health outcomes, including non-adherence to life-saving ART. For effective programming it is essential to identify factors associated with psychological outcomes in this population. Adopting a socioecological perspective, we aimed to identify correlates of internalising and externalising symptoms in a large, representative sample of South African adolescents living with HIV. HIV-positive adolescents (n = 1060), who received care in public health facilities in South Africa's Eastern Cape, completed measures of internalising and externalising symptoms. Hypothesised correlates included HIV and health-related factors (physical health, mode of infection, medication side-effects, disclosure, stigma), health-service related factors (negative interactions with clinic staff, clinic support group), interpersonal factors (abuse, bullying victimisation, social support), parenting-related factors (orphanhood, positive parenting, parental monitoring, parent communication), as well as individual and demographic-related factors (self-efficacy, age, gender, urban/rural location, poverty). Correlates operating across a variety of contexts were identified. Bullying victimisation, self-efficacy, and positive parenting may be particularly salient intervention targets as they were associated with better outcomes on most or all mental health measures, can be addressed without directly targeting adolescents living with HIV (reducing the chances of accidental exposure and stigma), and are associated with better adolescent mental health in South Africa more generally.

  • STACKing the odds for adolescent survival: health service factors associated with full retention in care and adherence amongst adolescents living with HIV in South Africa

    2018
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    Journal article
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    JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
    adolescent, HIV, delivery of healthcare, medication therapy management, adolescent health services, viral load

  • Household economic strengthening through financial and psychosocial programming: Evidence from a field experiment in South Africa

    2018
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    Journal article
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    JOURNAL OF DEVELOPMENT ECONOMICS
    Financial literacy, Saving, Parenting, RCT, South Africa

  • STACKing the odds for adolescent survival: health service factors associated with full retention in care and adherence amongst adolescents living with HIV in South Africa.

    2018
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    Journal article
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    Journal of the International AIDS Society
    INTRODUCTION:There are two million HIV-positive adolescents in southern Africa, and this group has low retention in care and high mortality. There is almost no evidence to identify which healthcare factors can improve adolescent self-reported retention. This study examines factors associated with retention amongst antiretroviral therapy (ART)-initiated adolescents in South Africa. METHODS:We collected clinical records and detailed standardized interviews (n = 1059) with all 10- to 19 year-olds ever initiated on ART in all 53 government clinics of a health subdistrict, and community traced to include lost-to-follow-up (90.1% of eligible adolescents interviewed). Associations between full self-reported retention in care (no past-year missed appointments and 85% past-week adherence) and health service factors were tested simultaneously in sequential multivariate regression and marginal effects modelling, controlling for covariates of age, gender, urban/rural location, formal/informal housing, maternal and paternal orphanhood, vertical/horizontal HIV infection, overall health, length of time on ART and type of healthcare facility. RESULTS:About 56% of adolescents had self-reported retention in care, validated against lower detectable viral load (AOR: 0.63, CI: 0.45 to 0.87, p = 0.005). Independent of covariates, five factors (STACK) were associated with improved retention: clinics Stocked with medication (OR: 3.0, CI: 1.6 to 5.5); staff with Time for adolescents (OR: 2.7, CI: 1.8 to 4.1); adolescents Accompanied to the clinic (OR: 2.3, CI: 1.5 to 3.6); enough Cash to get to clinic safely (OR: 1.4, CI: 1.1 to 1.9); and staff who are Kind (OR: 2.6, CI: 1.8 to 3.6). With none of these factors, 3.3% of adolescents reported retention. With all five factors, 69.5% reported retention. CONCLUSIONS:This study identifies key intervention points for adolescent retention in HIV care. A basic package of clinic and community services has the potential to STACK the odds for health and survival for HIV-positive adolescents.

  • Cash transfers to enhance TB control: lessons from the HIV response.

    2018
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    Journal article
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    BMC public health
    BACKGROUND:The World Health Organization prioritises a more holistic global response to end the tuberculosis (TB) epidemic by 2030. Based on experiences in the HIV response, social protection, and in particular cash transfers, show promise for contributing to this. Currently, individual-level evidence for the potential of cash transfers to prevent TB by addressing the structural social determinants of disease is lacking. To identify priority actions for the TB research agenda, we appraised efforts by the HIV response to establish the role of cash transfers in preventing HIV infection. MAIN BODY:The HIV response has evaluated the effects of cash transfers on risky sexual behaviours and HIV incidence. Work has also evaluated the added effects of supplementing cash transfers with psychosocial support. The HIV response has focused research on populations with disproportionate HIV risk, and used a mix of explanatory evaluations, which use ideal conditions, and pragmatic evaluations, which use operational conditions, to generate evidence that is both causally valid and applicable to the real world. It has always collaborated with multiple stakeholders in funding and evaluating projects. Learning from the HIV response, priority actions for the TB response should be to investigate the effect of cash transfers on intermediary social determinants of active TB disease, and TB incidence, as well as the added effects of supplementing cash transfers with psychosocial support. Work should be focused on key groups in high burden settings, and look to build a combination of explanatory and pragmatic evidence to inform policy decisions in this field. To achieve this, there is an urgent need to facilitate collaborations between groups interested in evaluating the impact of cash transfers on TB risk. CONCLUSIONS:The HIV response highlights several priority actions necessary for the TB response to establish the potential of cash transfers to prevent TB by addresing the structural social determinants of disease.
    Humans, Tuberculosis, HIV Infections, Public Policy, Health Promotion, Financing, Government, Africa, Social Determinants of Health

  • What Affects Attendance and Engagement in a Parenting Program in South Africa?

    2018
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    Journal article
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    Prevention science : the official journal of the Society for Prevention Research
    Parenting programs are a promising approach to improving family well-being. For families to benefit, programs need to be able to engage families actively in the interventions. Studies in high-income countries show varying results regarding whether more disadvantaged families are equally engaged in parenting interventions. In low- and middle-income countries (LMICs), almost nothing is known about the patterns of participation in parent training. This paper examines group session attendance and engagement data from 270 high-risk families enrolled in the intervention arm of a cluster-randomized controlled trial in South Africa. The trial evaluated a 14-week parenting intervention aiming to improve parenting and reduce maltreatment by caregivers. The intervention was delivered in 20 groups, one per study cluster, with 8 to 16 families each. Overall, caregivers attended 50% of group sessions and children, 64%. Using linear multilevel models with Kenward-Roger correction, we examined child and caregiver baseline characteristics as predictors of their attendance and engagement in the group sessions. Variables examined as predictors included measures of economic, educational, and social and health barriers and resources, as well as family problems and sociodemographic characteristics. Overall, the study yielded no evidence that the level of stressors, such as poverty, was related to attendance and engagement. Notably, children from overcrowded households attended on average 1.2 more sessions than their peers. Our findings suggest it is possible to engage highly disadvantaged families that face multiple challenges in parenting interventions in LMICs. However, some barriers such as scheduling, and alcohol and substance use, remain relevant.

  • OP29 Are socioeconomic conditions associated with asthma prevalence, severity, and treatment access? A cross-sectional study of children living in low-income South African communities

    2018
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    Journal article
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    Journal of Epidemiology and Community Health

  • 'Yummy or crummy?' The multisensory components of medicines-taking among HIV-positive youth.

    2018
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    Journal article
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    Global public health
    The global rollout of Antiretroviral Treatment (ART) has revealed an urgent need to understand the medicines-taking practices of HIV-positive adolescents. In the last decade, the literature on the social determinants of health has broadened the evidence-base on ART adherence. Interdisciplinary studies have expanded conceptions of medicines-taking beyond clinical or health systems frameworks, recognising the importance of socio-structural conditions and of patients' beliefs and experiences. Participatory research techniques which foreground the perspectives of adolescents provide greater insights still into their adherence. This article explores the use of participatory methods within a broader study on the social determinants of ART adherence among HIV-positive adolescents in South Africa. We describe how participatory methods were incorporated into this study (n = 1,059 in the quantitative baseline). We focus on an exercise, 'Yummy or crummy?', that explored the multisensory dimensions of medicines-taking, including their colour, smell, shape, and delivery mechanism. We describe two principal findings: first, adolescents' preference for greater understanding of the chemical workings of medicines, manifested in their preferences for colour, taste and shape of medicines; and second, the vital relationship between sensory preferences and the social imperatives of discretion and confidentiality regarding HIV-status.
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Lucie Cluver - CV (July 2018)

For information about new project 'Hey Baby', please go here.

Lucie's previous DPhil students have gone on to be successful in academia, policy and practice:

  • Caroline Kuo (2010) - is an Assistant Professor of Behavioral and Social Sciences in the Center for Alcohol and Addiction Studies at Brown University
  • Lena Saleh (2012) - is the Director of Program Planning in HIV Prevention in the New York City Department of Health and Mental Hygiene
  • Tyler Lane (2013) - is a research fellow in the Institute for Safety, Compensation and Recovery Research at Monash University
  • Franziska Meinck (2014) - is a postdoctoral researcher in the Centre for Evidence-Based Interventions at Oxford
  • Beth Vale (2015) - is a researcher in humanities at the Mapungubwe Institute for Strategic Reflection (MISTRA)
  • Jamie Lachman (2016) - is a postdoctoral researcher in the Centre for Evidence-Based Interventions at Oxford
  • Elona Toska (2017) -  is a postdoctoral researcher at the University of Cape Town

Lucie would welcome applications for D.Phils from students who are committed to policy and programming-relevant research and to helping mitigate the impacts of HIV/AIDS and family distress on children in sub-Saharan Africa.

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